Vascular Inflammation and Endothelial Dysfunction in Experimental Hypertension. (11th September 2011)

• Record Type: Journal Article
• Authors: Savoia, Carmine; Sada, Lidia; Zezza, Luigi; Pucci, Lorenzo; Lauri, Francesco Maria; Befani, Alberto; Alonzo, Alessandro; Volpe, Massimo
• Other Names: Unger Thomas Academic Editor.
• Is Part Of: International journal of hypertension. Volume 2011(2011)
• Publication Date: 2011-09-11
• Subjects: Hypertension -- Periodicals; Hypertension; Hypertension; Periodicals; 616.132005
• DOI: 10.4061/2011/281240
• Languages: English
• ISSNs: 2090-0384

Abstract

Abstract : Essential hypertension is characterized by increased peripheral vascular resistance to blood flow. The endothelium is a crucial regulator of vascular tone. Its function is impaired in patients with hypertension, with reduced vasodilation, increased vascular tone associated with a proinflammatory and prothrombotic state. Low-grade inflammation localized in vascular tissue is therefore recognized as an important contributor to the pathophysiology of hypertension, to the initiation and progression of atherosclerosis as well as to the development of cardiovascular diseases.