A "kissing lesion": In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis. (July 2017)

• Record Type: Journal Article
• Authors: Kolber, Pierre; Droby, Amgad; Roebroeck, Alard; Goebel, Rainer; Fleischer, Vinzenz; Groppa, Sergiu; Zipp, Frauke
• Is Part Of: Multiple sclerosis. Volume 23:Number 8(2017)
• Page Start: 1167
• Page End: 1169
• Publication Date: 2017-07
• Subjects: Multiple sclerosis -- 7T -- atypical cortical lesions -- magnetic resonance imaging; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458516683267
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: The role of cortical lesions (CLs) in disease progression and clinical deficits is increasingly recognized in multiple sclerosis (MS); however the origin of CLs in MS still remains unclear. Objective: Here, we report a para-sulcal CL detected two years after diagnosis in a relapsing-remitting MS (RRMS) patient without manifestation of clinical deficit. Methods: Ultra-high field (7T) MR imaging using magnetization-prepared 2 rapid acquisition gradient echoes (MP2RAGE) sequence was performed. Results: A para-sulcal CL was detected which showed hypointense rim and iso- to hyperintense core. This was detected in the proximity of the leptomeninges in the left precentral gyrus extending to the adjacent postcentral gyrus. Conclusion: This finding indicates that inflammatory infiltration into the cortex through the meninges underlies cortical pathology already in the early stage of disease and in mild disease course.