Why non-inferiority is more challenging than superiority?. (May 2017)

• Record Type: Journal Article
• Authors: Sormani, Maria Pia
• Is Part Of: Multiple sclerosis. Volume 23:Number 6(2017)
• Page Start: 790
• Page End: 791
• Publication Date: 2017-05
• Subjects: Multiple sclerosis -- clinical trials -- non-inferiority; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458517703805
• Languages: English
• ISSNs: 1352-4585

Abstract

Demonstrating non-inferiority in clinical trials is usually more challenging than showing superiority. In multiple sclerosis (MS), non-inferiority trials are rarely designed since they would require prohibitive sample sizes. In this brief report, the reasons why non-inferiority trials are usually larger than superiority trials is explored.