Regulation of Breast Cancer and Bone Metastasis by MicroRNAs. Issue 5 (26th September 2013)

• Record Type: Journal Article
• Authors: Vimalraj, S.; Miranda, P. J.; Ramyakrishna, B.; Selvamurugan, N.
• Other Names: Dugue Benoit Academic Editor.
• Is Part Of: Disease markers. Volume 35:Issue 5(2013)
• Page Start: 369
• Page End: 387
• Publication Date: 2013-09-26
• Subjects: Diagnosis -- Periodicals; Biochemical markers -- Periodicals; Pathology -- Periodicals; 616
• DOI: 10.1155/2013/451248
• Languages: English
• ISSNs: 0278-0240

Abstract

Abstract : Breast cancer progression including bone metastasis is a complex process involving numerous changes in gene expression and function. MicroRNAs (miRNAs) are small endogenous noncoding RNAs that regulate gene expression by targeting protein-coding mRNAs posttranscriptionally, often affecting a number of gene targets simultaneously. Alteration in expression of miRNAs is common in human breast cancer, possessing with either oncogenic or tumor suppressive activity. The expression and the functional role of several miRNAs (miR-206, miR-31, miR-27a/b, miR-21, miR-92a, miR-205, miR-125a/b, miR-10b, miR-155, miR-146a/b, miR-335, miR-204, miR-211, miR-7, miR-22, miR-126, and miR-17) in breast cancer has been identified. In this review we summarize the experimentally validated targets of up- and downregulated miRNAs and their regulation in breast cancer and bone metastasis for diagnostic and therapeutic purposes.