Synthesis, Antimicrobial, and Anticoagulant Activities of 2-(Arylsulfonyl)indane-1, 3-diones. (15th July 2011)

• Record Type: Journal Article
• Authors: Jeyachandran, Malaichamy; Ramesh, Penugonda
• Other Names: Ogilvie William Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2011(2011)
• Publication Date: 2011-07-15
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2011/360810
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : 2-(Arylsulfonyl)indane-1, 3-diones, earlier synthesized by Claisen condensation involving diethyl phthalate and aryl methyl sulphones, are found to be potent blood anticoagulants. In search of improved analogs of 2-(arylsulfonyl)indane-1, 3-dione, we have synthesized them(7 a-f) by a different route involving Knoevenagel reaction between phthalic anhydride and arylsulfonylacetates in the presence of pyridine-piperidine medium for the first time. The synthesized 2-(arylsulfonyl)indane-1, 3-diones were evaluated for antimicrobial and anticoagulant activities and all of them registered significant activity.