Synthesis of Bis-2, 3-dihydroquinazolin-4(1H)-ones and 2, 3-Dihydroquinazolin-4(1H)-ones Derivatives with the Aid of Silica-Supported Preyssler Nanoparticles. (10th September 2013)

• Record Type: Journal Article
• Authors: Gharib, Ali; Hashemipour Khorasani, Bibi Robabeh; Jahangir, Manouchehr; Roshani, Mina; Safaee, Reza
• Other Names: Aly Shehata Ashraf Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2013(2013)
• Publication Date: 2013-09-10
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2013/848237
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : One-pot three-component condensation of isatoic anhydride with primary amines or ammonium carbonate and aromatic aldehydes in refluxing ethanol in the presence of catalytic amounts of silica-supported preyssler nanoparticles (SPNP) afforded the corresponding 2, 3-dihydroquinazolin-4(1 H )-ones in high yields, and bis-dihydroquinazolinones were synthesized for the first time by a novel pseudo-five-component condensation of isatoic anhydride, a primary amine, and a dialdehyde in water. The catalyst is reusable and can be applied several times without any decrease in product yield.