Synthesis of Pyrazine Substituted 1, 3, 4-Thiadiazole Derivatives and Their Anticonvulsant Activity. (4th December 2013)

• Record Type: Journal Article
• Authors: Harish, Kikkeri P.; Mohana, Kikkeri N.; Mallesha, Lingappa
• Other Names: Aly Shehata Ashraf Academic Editor.
• Is Part Of: Organic chemistry international. Volume 2013(2013)
• Publication Date: 2013-12-04
• Subjects: Chemistry, Organic -- Periodicals; Chemistry, Organic; Periodicals; 547
• DOI: 10.1155/2013/631723
• Languages: English
• ISSNs: 2090-200X

Abstract

Abstract : The synthesis of new pyrazine substituted 1, 3, 4-thiadiazole derivatives was carried out in good yield by the reaction of pyrazine substituted 1, 3, 4-thiadiazoles with various sulfonyl chlorides. A chemical structure of all the new compounds was confirmed by 1 H NMR and mass spectral data. The new compounds were screened for their anticonvulsant activity against maximal electroshock (MES) seizure method. Rotarod method was employed to determine the neurotoxicity. Few compounds showed significant changes in anticonvulsant activity. The same compounds showed no neurotoxicity at the maximum dose administered (100 mg/kg).