Intrathyroidal Parathyroid Carcinoma: Report of an Unusual Case and Review of the Literature. (14th July 2013)

• Record Type: Journal Article
• Authors: Vila Duckworth, Lizette; Winter, William E.; Vaysberg, Mikhail; Moran, César A.; Al-Quran, Samer Z.
• Other Names: Aozasa K. Academic Editor.; Batinac T. Academic Editor.; Hasebe T. Academic Editor.; Perrini P. Academic Editor.; Picken M. M. Academic Editor.; Tosi P. Academic Editor.; Tot T. Academic Editor.
• Is Part Of: Case reports in pathology. Volume 2013(2013)
• Publication Date: 2013-07-14
• Subjects: Pathology -- Periodicals; Pathology; Pathology; Electronic journals; Periodicals; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.07
• DOI: 10.1155/2013/198643
• Languages: English
• ISSNs: 2090-6781

Abstract

Abstract : Intrathyroidal parathyroid carcinoma is an exceedingly rare cause of primary hyperparathyroidism. A 51-year-old African American female presented with goiter, hyperparathyroidism, and symptomatic hypercalcemia. Sestamibi scan revealed diffuse activity within an enlarged thyroid gland with uptake in the right thyroid lobe suggestive of hyperfunctioning parathyroid tissue. The patient underwent thyroidectomy and parathyroidectomy. At exploration, a 2.0 cm nodule in the usual location of the right inferior parathyroid was sent for intraoperative frozen consultation, which revealed only ectopic thyroid tissue. No parathyroid glands were identified grossly on the external aspect of the thyroid. Interestingly, postoperative parathyroid hormone levels normalized after removal of the thyroid gland. Examination of the thyroidectomy specimen revealed a 1.4 cm parathyroid nodule located within the parenchyma of the right superior thyroid, with capsular and vascular invasion and local infiltration into surrounding thyroid tissue. We present only the eighth reported case of intrathyroidal parathyroid carcinoma and review the literature.