A contemporary biological pathway of islet amyloid polypeptide for the management of diabetic dementia. (1st June 2019)

• Record Type: Journal Article
• Authors: Sah, Sushil Kumar; Samuel, Vijaya Paul; Dahiya, Sunita; Singh, Yogendar; Gilhotra, Ritu M.; Gupta, Gaurav; Mishra, Anurag; Sharma, Rakesh Kumar; Kumar, Gubbiyappa Shiva; SreeHarsha, Nagaraja; Chellappan, Dinesh Kumar; Dua, Kamal
• Is Part Of: Chemico-biological interactions. Volume 306(2019)
• Page Start: 117
• Page End: 122
• Publication Date: 2019-06-01
• Subjects: Diabetes mellitus -- Cognitive dysfunction -- Islet amyloid polypeptide -- Amylin -- CGRP receptor; Biochemistry -- Periodicals; Toxicological chemistry -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biochimie -- Périodiques; Toxicologie biochimique -- Périodiques; 572
• DOI: 10.1016/j.cbi.2019.04.022
• Languages: English
• ISSNs: 0009-2797

Abstract

Abstract: Major challenges of dealing elder patients with diabetes mellitus (DM) are the individualization of consideration in persons with various comorbid types of conditions. In spite of the fact that microvascular and macrovascular problems associated with DM are well documented, there is only a few numbers of reports viewing different conditions, for example, cognitive dysfunction. Cognitive dysfunction is of specific significance due to its effect on self-care and quality of life. All in all, the etiology of cognitive dysfunction in the maturing populace is probably going to be the grouping of ischemic and degenerative pathology. It is likewise trusted that Hyperglycemia is engaged with the system of DM-related cognitive dysfunction. At present, it isn't certain in the case of enhancing glycemic control or utilizing therapeutic agents can enhance the risk of cognitive decay. Amylin was later characterized as an amyloidogenic peptide, confined from a beta cell tumor and called islet amyloid polypeptide (IAPP), and after that, amylin. Conversely, we investigate the beneficial role and hypothesizing the mechanism of amylin related expanding the level and activation of CGRP receptor to enhance the cognition declination amid diabetic dementia. Highlights: Amylin is a pancreatic hormone regulates glucose blood through decreasing feeding. Amylin amyloids are harmful in the type 2 diabetes and likely Alzheimer disease. Amylin activates CGRP to enhance the cognition declination amid diabetic dementia.