Cortico-limbic pain mechanisms. (29th May 2019)

• Record Type: Journal Article
• Authors: Thompson, Jeremy M.; Neugebauer, Volker
• Is Part Of: Neuroscience letters. Volume 702(2019)
• Page Start: 15
• Page End: 23
• Publication Date: 2019-05-29
• Subjects: ACC anterior cingulate cortex -- Ach acetylcholine -- BLA basolateral amygdala -- CB cannabinoid receptor -- Cdk5 cyclin-dependent kinase 5 -- CeA central nucleus of the amygdala -- CeL lateral division of the CeA -- CeM medial division of the CeA -- CFA complete Freund's adjuvant -- CA cornu ammonis -- CRF corticotropin releasing factor -- CRPS complex regional pain syndrome -- DG dentate gyrus -- EPSC excitatory postsynaptic current -- FST forced swim test -- ERK extracellular signal-regulated kinase -- HCN hyperpolarization-activated cyclic nucleotide–gated channel -- IC insular cortex -- IL interleukin -- i.p. intraperitoneal -- IPSC inhibitory postsynaptic current -- ITC intercalated cell mass of the amygdala -- iSPN indirect spiny projection neuron -- LA lateral amygdala -- LA/BLA lateral/basolateral amygdala nuclei -- mGluR metabotropic glutamate receptor -- mPFC medial prefrontal cortex -- NAc nucleus accumbens -- NMDA N-methyl-d-aspartate -- NPS neuropeptide S -- PAG periaqueductal gray -- PB parabrachial nucleus -- PV parvalbumin -- SPT sucrose preference test -- SNI spared nerve injury -- SNL spinal nerve ligation -- TNF-α tumor necrosis factor alpha -- VTA ventral tegmental area; Prefrontal cortex -- Amygdala -- Hippocampus -- Nucleus accumbens -- Pain modulation -- Cognitive -- Affective -- Vulnerability -- Neuroplasticity; Neurology -- Periodicals; Neurology -- Periodicals; Research -- Periodicals; Neurologie -- Périodiques; Neuroanatomie -- Périodiques; Neuropharmacologie -- Périodiques; Neurophysiologie -- Périodiques; Neurology; Periodicals; Electronic journals; 617.48
• DOI: 10.1016/j.neulet.2018.11.037
• Languages: English
• ISSNs: 0304-3940

Abstract

Abstract: Pain has a strong emotional component and is defined by its unpleasantness. Chronic pain represents a complex disorder with anxio-depressive symptoms and cognitive deficits. Underlying mechanisms are still not well understood but an important role for interactions between prefrontal cortical areas and subcortical limbic structures has emerged. Evidence from preclinical studies in the rodent brain suggests that neuroplastic changes in prefrontal (anterior cingulate, prelimbic and infralimbic) cortical and subcortical (amygdala and nucleus accumbens) brain areas and their interactions (corticolimbic circuitry) contribute to the complexity and persistence of pain and may be predetermining factors as has been proposed in recent human neuroimaging studies.