Successful Desensitization of a Patient with Rituximab Hypersensitivity. (20th January 2015)

• Record Type: Journal Article
• Authors: Ataca, Pinar; Atilla, Erden; Kendir, Resat; Bavbek, Sevim; Ozcan, Muhit
• Other Names: Mansour Ahmad M. Academic Editor.
• Is Part Of: Case reports in immunology. Volume 2015(2015)
• Publication Date: 2015-01-20
• Subjects: Immunology -- Periodicals; Immunology -- Case studies -- Periodicals; Immune System Phenomena; Immunology; Immunology; Case studies; Periodicals; 571.96
• DOI: 10.1155/2015/524507
• Languages: English
• ISSNs: 2090-6609

Abstract

Abstract : Rituximab is a monoclonal antibody which targets CD20 in B cells that is used for the treatment of CD20 positive oncologic and hematologic malignancies. Rituximab causes hypersensitivity reactions during infusions. The delay of treatment or loss of a highly efficient drug can be prevented by rapid drug desensitization method in patients who are allergic to rituximab. We report a low grade B cell non-Hodgkin lymphoma patient with rituximab hypersensitivity successfully treated with rapid drug desensitization. In experienced centers, drug desensitization is a novel modality to break through in case of hypersensitivity that should be considered.