Modeling Airflow Using Subject-Specific 4DCT-Based Deformable Volumetric Lung Models. (20th December 2012)

• Record Type: Journal Article
• Authors: Ilegbusi, Olusegun J.; Li, Zhiliang; Seyfi, Behnaz; Min, Yugang; Meeks, Sanford; Kupelian, Patrick; Santhanam, Anand P.
• Other Names: El-Baz Ayman Academic Editor.
• Is Part Of: International journal of biomedical imaging. Volume 2012(2012)
• Publication Date: 2012-12-20
• Subjects: Diagnostic imaging -- Periodicals; Imaging systems in medicine -- Periodicals; Imagerie pour le diagnostic; Imagerie médicale; Diagnostic imaging; Imaging systems in medicine; Diagnostic Imaging -- Periodicals; Electronic journals; Periodicals; 616.0754
• DOI: 10.1155/2012/350853
• Languages: English
• ISSNs: 1687-4188

Abstract

Abstract : Lung radiotherapy is greatly benefitted when the tumor motion caused by breathing can be modeled. The aim of this paper is to present the importance of using anisotropic and subject-specific tissue elasticity for simulating the airflow inside the lungs. A computational-fluid-dynamics (CFD) based approach is presented to simulate airflow inside a subject-specific deformable lung for modeling lung tumor motion and the motion of the surrounding tissues during radiotherapy. A flow-structure interaction technique is employed that simultaneously models airflow and lung deformation. The lung is modeled as a poroelastic medium with subject-specific anisotropic poroelastic properties on a geometry, which was reconstructed from four-dimensional computed tomography (4DCT) scan datasets of humans with lung cancer. The results include the 3D anisotropic lung deformation for known airflow pattern inside the lungs. The effects of anisotropy are also presented on both the spatiotemporal volumetric lung displacement and the regional lung hysteresis.