Feasibility of Imaging Myelin Lesions in Multiple Sclerosis. (15th August 2011)

• Record Type: Journal Article
• Authors: Zavodszky, Maria I.; Graf, John F.; Tan Hehir, Cristina A.
• Other Names: Erlandsson Kjell Academic Editor.
• Is Part Of: International journal of biomedical imaging. Volume 2011(2011)
• Publication Date: 2011-08-15
• Subjects: Diagnostic imaging -- Periodicals; Imaging systems in medicine -- Periodicals; Imagerie pour le diagnostic; Imagerie médicale; Diagnostic imaging; Imaging systems in medicine; Diagnostic Imaging -- Periodicals; Electronic journals; Periodicals; 616.0754
• DOI: 10.1155/2011/953806
• Languages: English
• ISSNs: 1687-4188

Abstract

Abstract : The goal of this study was to provide a feasibility assessment for PET imaging of multiple sclerosis (MS) lesions based on their decreased myelin content relative to the surrounding normal-appearing brain tissue. The imaging agent evaluated for this purpose is a molecule that binds strongly and specifically to myelin basic protein. Physiology-based pharmacokinetic modeling combined with PET image simulation applied to a brain model was used to examine whether such an agent would allow the differentiation of artificial lesions 4–10 mm in diameter from the surrounding normal-looking white and gray matter. Furthermore, we examined how changes in agent properties, model parameters, and experimental conditions can influence imageability, identifying a set of conditions under which imaging of MS lesions might be feasible. Based on our results, we concluded that PET imaging has the potential to become a useful complementary method to MRI for MS diagnosis and therapy monitoring.