Landmark Optimization Using Local Curvature for Point-Based Nonlinear Rodent Brain Image Registration. (26th September 2011)

• Record Type: Journal Article
• Authors: Liu, Yutong; Sajja, Balasrinivasa R.; Uberti, Mariano G.; Gendelman, Howard E.; Kielian, Tammy; Boska, Michael D.
• Other Names: Parsey Ramin Academic Editor.
• Is Part Of: International journal of biomedical imaging. Volume 2012(2012)
• Publication Date: 2011-09-26
• Subjects: Diagnostic imaging -- Periodicals; Imaging systems in medicine -- Periodicals; Imagerie pour le diagnostic; Imagerie médicale; Diagnostic imaging; Imaging systems in medicine; Diagnostic Imaging -- Periodicals; Electronic journals; Periodicals; 616.0754
• DOI: 10.1155/2012/635207
• Languages: English
• ISSNs: 1687-4188

Abstract

Abstract : Purpose . To develop a technique to automate landmark selection for point-based interpolating transformations for nonlinear medical image registration. Materials and Methods . Interpolating transformations were calculated from homologous point landmarks on the source (image to be transformed) and target (reference image). Point landmarks are placed at regular intervals on contours of anatomical features, and their positions are optimized along the contour surface by a function composed of curvature similarity and displacements of the homologous landmarks. The method was evaluated in two cases (n = 5 each). In one, MRI was registered to histological sections; in the second, geometric distortions in EPI MRI were corrected. Normalized mutual information and target registration error were calculated to compare the registration accuracy of the automatically and manually generated landmarks. Results . Statistical analyses demonstrated significant improvement (P < 0.05 ) in registration accuracy by landmark optimization in most data sets and trends towards improvement (P < 0.1 ) in others as compared to manual landmark selection.