A Clinical-EEG Study of Sleepiness and Psychological Symptoms in Pharmacoresistant Epilepsy Patients Treated with Lacosamide. (19th September 2013)

• Record Type: Journal Article
• Authors: Giorgi, Filippo S.; Pizzanelli, Chiara; Pelliccia, Veronica; Di Coscio, Elisa; Maestri, Michelangelo; Guida, Melania; Iacopini, Elena; Iudice, Alfonso; Bonanni, Enrica
• Other Names: Romigi Andrea Academic Editor.
• Is Part Of: Epilepsy research and treatment. Volume 2013(2013)
• Publication Date: 2013-09-19
• Subjects: Brain -- Diseases -- Periodicals; Epilepsy -- Periodicals; Neurology -- Periodicals; Brain Diseases; Epilepsy; Neurology; Brain -- Diseases; Epilepsy; Neurology; Brain Diseases -- Periodicals; Brain -- Diseases -- Periodicals; Epilepsy -- Periodicals; Neurology -- Periodicals; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.853
• DOI: 10.1155/2013/593149
• Languages: English
• ISSNs: 2090-1348

Abstract

Abstract : Our aim was to evaluate the EEG and clinical modifications induced by the new antiepileptic drug lacosamide (LCM) in patients with epilepsy. We evaluated 10 patients affected by focal pharmacoresistant epilepsy in which LCM (mean 250 mg/day) was added to the preexisting antiepileptic therapy, which was left unmodified. Morning waking EEG recording was performed before ( t 0) and at 6 months ( t 1) after starting LCM. At t 0 and t 1, patients were also administered questionnaires evaluating mood, anxiety, sleep, sleepiness, and fatigue (Beck Depression Inventory; State-Trait Anxiety Inventory Y1 and Y2; Pittsburgh Sleep Quality Index; Epworth Sleepiness Scale; Fatigue Severity Scale). We performed a quantitative analysis of EEG interictal abnormalities and background EEG power spectrum analysis. LCM as an add-on did not significantly affect anxiety, depression, sleepiness, sleep quality, and fatigue scales. Similarly, adding LCM to preexisting therapy did not modify significantly patient EEGs in terms of absolute power, relative power, mean frequency, and interictal abnormalities occurrence. In conclusion, in this small cohort of patients, we confirmed that LCM as an add-on does not affect subjective parameters which play a role, among others, in therapy tolerability, and our clinical impression was further supported by evaluation of EEG spectral analysis.