HPV Prevalence in Colombian Women with Cervical Cancer: Implications for Vaccination in a Developing Country. (24th November 2009)

• Record Type: Journal Article
• Authors: Murillo, Raúl; Molano, Mónica; Martínez, Gilberto; Mejía, Juan-Carlos; Gamboa, Oscar
• Other Names: Harper Diane Academic Editor.
• Is Part Of: Infectious diseases in obstetrics and gynecology. Volume 2009(2009)
• Publication Date: 2009-11-24
• Subjects: Generative organs, Female -- Infections -- Periodicals; Communicable diseases in pregnancy -- Periodicals; 618.142005
• DOI: 10.1155/2009/653598
• Languages: English
• ISSNs: 1064-7449

Abstract

Abstract : Human Papillomavirus (HPV) vaccines have been considered potentially cost-effective for the reduction of cervical cancer burden in developing countries; their effectiveness in a public health setting continues to be researched. We conducted an HPV prevalence survey among Colombian women with invasive cancer. Paraffin-embedded biopsies were obtained from one high-risk and one low-middle-risk regions. GP5+/GP6+ L1 primers, RLB assays, and E7 type specific PCR were used for HPV-DNA detection. 217 cases were analyzed with 97.7% HPV detection rate. HPV-16/18 prevalence was 63.1%; HPV-18 had lower occurrence in the high-risk population (13.8% versus 9.6%) allowing for the participation of less common HPV types; HPV-45 was present mainly in women under 50 and age-specific HPV type prevalence revealed significant differences. Multiple high-risk infections appeared in 16.6% of cases and represent a chance of replacement. Age-specific HPV prevalence and multiple high-risk infections might influence vaccine impact. Both factors highlight the role of HPVs other than 16/18, which should be considered in cost-effectiveness analyses for potential vaccine impact.