Effects of lercanidipine hydrochloride versus felodipine sustained-release on day-to-day home blood pressure variability. (30th September 2016)

• Record Type: Journal Article
• Authors: Xu, Mengdan; Wu, Ying; Wang, Hao; Xu, Xin; Zhao, Shuiping; Zhang, Mei; Jin, Huigen-; Yan, Jinchuan; Wang, Bangning; Gong, Jianbin; Lu, Xiang; Peng, Jianqiang; Dai, Qiuyan
• Is Part Of: Current medical research and opinion. Volume 32(2016)Supplement 2
• Page Start: 43
• Page End: 52
• Publication Date: 2016-09-30
• Subjects: Blood pressure -- Felodipine -- Hypertension -- Lercanidipine; Clinical medicine -- Periodicals; Therapeutics -- Periodicals; 615.5
• DOI: 10.1080/03007995.2016.1220932
• Languages: English
• ISSNs: 0300-7995

Abstract

Abstract: Objective: The objective of this study was to compare the effectiveness of lercanidipine with felodipine in patients with mild-to-moderate hypertension on day-to-day home blood pressure variability. Methods: This is a sub-study of a multicenter, randomized, open-label, parallel group and active controlled clinical trial. Hypertensive patients aged 18–75 (i.e. diastolic blood pressure ≥90 mmHg and <110 mmHg; systolic blood pressure ≥140 mmHg and <180 mmHg) and 24 h mean BP >130/80 mmHg) were eligible for this study. During the study, blood pressure (BP) and heart rate (HR) were recorded. The day-to-day BP variability (BPV) and HR variability (HRV) were obtained by the standard deviation (SD) of daily BP/HR average (of six readings) in 7 days. Results: There were 186 patients (89 and 97 patients in the lercanidipine and felodipine groups, respectively) included in this study. Lercanidipine hydrochloride 10 mg/d and felodipine sustained-release tablets 5 mg/d were given to their respective groups. After 6 weeks of treatment, SD of home BP significantly reduced compared with baseline in both groups ( P < .05) while SD of home HR also changed significantly after treatment ( P < .05). There was no significant difference in SD of home BPV between the lercanidipine and felodipine groups after treatment. Conclusion: Treatment with lercanidipine and felodipine both resulted in reduction of BPV and HRV. There was no significant inter-group difference in reduction of BPV between the groups. Lercanidipine is an effective antihypertensive drug in improving BPV. National clinical trial: NCT01520285.