Fulminant Type 1 Diabetes as a Model of Nature to Explore the Role of C-Peptide. (15th April 2008)

• Record Type: Journal Article
• Authors: Murase-Mishiba, Yuko; Imagawa, A.; Hanafusa, Toshiaki
• Other Names: Forst Thomas Academic Editor.
• Is Part Of: Experimental diabetes research. Volume 2008(2008)
• Publication Date: 2008-04-15
• Subjects: Diabetes -- Research -- Periodicals; Diabetes -- Research; Periodicals; 616.462
• DOI: 10.1155/2008/819123
• Languages: English
• ISSNs: 1687-5214

Abstract

Abstract : Patients with fulminant type 1 diabetes almost completely lack C-peptide even soon after the onset of the disease, and the deficiency continues for the rest of their life. Thus, fulminant type 1 diabetes could serve as a good model of nature to explore the physiological role of C-peptide. For example, patients with fulminant type 1 diabetes have diabetic chronic complications more frequently than those with classical autoimmune type 1 diabetes 5 years after the onset of diabetes, and the higher prevalence could be partly attributable to the complete lack of C-peptide in fulminant type 1 diabetes.