Cardiac Autonomic Function Correlates with Arterial Stiffness in the Early Stage of Type 1 Diabetes. (24th July 2011)

• Record Type: Journal Article
• Authors: Liatis, S.; Alexiadou, K.; Tsiakou, A.; Makrilakis, K.; Katsilambros, N.; Tentolouris, N.
• Other Names: Kokkinos Alexander Academic Editor.
• Is Part Of: Experimental diabetes research. Volume 2011(2011)
• Publication Date: 2011-07-24
• Subjects: Diabetes -- Research -- Periodicals; Diabetes -- Research; Periodicals; 616.462
• DOI: 10.1155/2011/957901
• Languages: English
• ISSNs: 1687-5214

Abstract

Abstract : Arterial stiffness is increased in type 1 diabetes (T1D), before any clinical complications of the disease are evident. The aim of the present paper was to investigate the association between cardiac autonomic function and arterial stiffness in a cohort of young T1D patients, without history of hypertension and any evidence of macrovascular and/or renal disease. Large artery stiffness was assessed by measurement of carotid-femoral pulse wave velocity (PWV). Cardiac autonomic function was assessed by the cardiovascular tests proposed by Ewing and Clarke. Patients with a high cardiac autonomic neuropathy score (≥ 4) had significantly higher PWV than those with a low score (0-1). A negative, heart rate-independent, correlation between PWV and heart rate variation during respiration was observed (r = − 0.533, P < 0.001 ). In multivariable analysis, E / I index was the strongest correlate of PWV ( β -coefficient = −0.326, P = 0.002 ). Cardiac parasympathetic function is a strong predictor of large arterial stiffness, in young T1D patients free of macrovascular and renal complications.