Effect of Food Restriction on Adipose Tissue in Spontaneously Diabetic Torii Fatty Rats. (14th July 2009)

• Record Type: Journal Article
• Authors: Morinaga, Hisayo; Ohta, Takeshi; Matsui, Kenichi; Sasase, Tomohiko; Fukuda, Sumiaki; Ito, Makoto; Ueda, Masatoshi; Ishii, Yukihito; Miyajima, Katsuhiro; Matsushita, Mutsuyoshi
• Other Names: Kikkawa Ryuichi Academic Editor.
• Is Part Of: Experimental diabetes research. Volume 2009(2009)
• Publication Date: 2009-07-14
• Subjects: Diabetes -- Research -- Periodicals; Diabetes -- Research; Periodicals; 616.462
• DOI: 10.1155/2009/715057
• Languages: English
• ISSNs: 1687-5214

Abstract

Abstract : Spontaneously Diabetic Torii- fa/fa (SDT fatty) rat is a new model of obese type 2 diabetes. SDT fatty rat exhibits obesity associated with hyperphagia. In this study, SDT fatty rats were subjected to pair-feeding with SDT-+/+ (SDT) rats from 6 to 22 weeks of age. The ratio of visceral fat weight to subcutaneous fat weight (V/S) decreased at 12 weeks of age in the pair-feeding rats. The intraperitoneal fat weight such as epididymal and retroperitoneal fat weight decreased, whereas mesenteric fat weight had no change. Cell size of the epididymal fat in the pair-feeding rats tended to decrease. Glucose oxidation level in epididymal fat in the pair-feeding rats at 12 weeks of age was recovered to a similar level with that in SDT rats. These results indicated that SDT fatty rat is a useful model to evaluate the functional or the morphological features in adipose tissue and develop a novel drug for antiobesity.