Atypical clinical features associated with mixed pathology in a case of non-fluent variant primary progressive aphasia. Issue 1 (4th March 2019)

• Record Type: Journal Article
• Authors: De Leon, Jessica; Mandelli, Maria Luisa; Nolan, Amber; Miller, Zachary A.; Mead, Christie; Watson, Christa; Welch, Ariane E; Henry, Maya L; Bourakova, Viktoriya; La Joie, Renaud; Bajorek, Lynn P.; Grinberg, Lea; Rabinovici, Gil; Miller, Bruce L.; Gorno-Tempini, Maria Luisa
• Is Part Of: Neurocase. Volume 25:Issue 1/2(2019)
• Page Start: 39
• Page End: 47
• Publication Date: 2019-03-04
• Subjects: Non-fluent agrammatic primary progressive aphasia -- syntax network -- corticobasal degeneration -- Alzheimer's disease neuropathology -- TDP-43 type A neuropathology; Neurology -- Periodicals; Neuropsychology -- Case Report; Mental Disorders -- Case Report; Nervous System Diseases -- Case Report; 616.8
• DOI: 10.1080/13554794.2019.1609522
• Languages: English
• ISSNs: 1355-4794

Abstract

ABSTRACT: A 66-year-old woman presented with agrammatism and apraxia of speech, meeting criteria for non-fluent/agrammatic variant primary progressive aphasia (nfvPPA). However, three years later, she developed frontal/executive, short-term phonological memory, visuospatial, and visual memory deficits suggesting involvement of multiple brain networks. Multimodal neuroimaging showed damage of both fronto-striatal and posterior brain regions. She was found to have multiple pathological processes: corticobasal degeneration (CBD), Alzheimer's disease (AD), and TAR DNA-binding protein (TDP)-43 type A. We hypothesize that cognitive and neuroimaging findings consistent with damage to multiple brain networks, each associated with vulnerability to certain molecular disease subtypes, could indicate mixed pathology.