Antioxidant Therapy in Nonalcoholic Steatohepatitis. (22nd November 2012)

• Record Type: Journal Article
• Authors: Al-Busafi, Said A.; Bhat, Mamatha; Wong, Philip; Ghali, Peter; Deschenes, Marc
• Other Names: Van Thiel David Hoffman Academic Editor.
• Is Part Of: Hepatitis research and treatment. Volume 2012(2012)
• Publication Date: 2012-11-22
• Subjects: Hepatitis -- Periodicals; Hepatitis; Hepatitis; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.3623
• DOI: 10.1155/2012/947575
• Languages: English
• ISSNs: 2090-1364

Abstract

Abstract : Nonalcoholic steatohepatitis (NASH) affects up to 3% of the North American population. It occurs as a manifestation of the insulin-resistant state and oxidative stress is thought to be a key component of its pathophysiology. Exercise and diet, which are the mainstay of therapy, are difficult to achieve and maintain with a disappointing long-term compliance record. There is growing literature on the potential for antioxidant therapy. The recent literature strongly suggests that vitamin E supplementation and other putative free radical scavengers and/or antioxidants are beneficial in improving biochemical and histological parameters in NASH.