Can Engineered "Designer" T Cells Outsmart Chronic Hepatitis B?. (1st August 2010)

• Record Type: Journal Article
• Authors: Protzer, U.; Abken, H.
• Other Names: Prince Alfred M. Academic Editor.
• Is Part Of: Hepatitis research and treatment. Volume 2010(2010)
• Publication Date: 2010-08-01
• Subjects: Hepatitis -- Periodicals; Hepatitis; Hepatitis; Electronic journals; Periodical; Periodicals; Fulltext; Internet Resources; Periodicals; 616.3623
• DOI: 10.1155/2010/901216
• Languages: English
• ISSNs: 2090-1364

Abstract

Abstract : More than 350 million people worldwide are persistently infected with human heptatitis B virus (HBV) and at risk to develop liver cirrhosis and hepatocellular carcinoma making long-term treatment necessary. While a vaccine is available and new antiviral drugs are being developed, elimination of persistently infected cells is still a major issue. Recent efforts in adoptive cell therapy are experimentally exploring immunotherapeutic elimination of HBV-infected cells by means of a biological attack with genetically engineered "designer" T cells.