Degradable Vanadium Disulfide Nanostructures with Unique Optical and Magnetic Functions for Cancer Theranostics. Issue 42 (6th September 2017)

• Record Type: Journal Article
• Authors: Chen, Yuyan; Cheng, Liang; Dong, Ziliang; Chao, Yu; Lei, Huali; Zhao, He; Wang, Jian; Liu, Zhuang
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 42(2017)
• Page Start: 12991
• Page End: 12996
• Publication Date: 2017-09-06
• Subjects: multimodal imaging -- nanomedicine -- photothermal therapy -- toxicity -- VS2 nanostructures; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201707128
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Multifunctional biodegradable inorganic theranostic nano‐agents are of great interest to the field of nanomedicine. Upon lipid modification, VS2 nanosheets could be converted into ultra‐small VS2 nanodots encapsulated inside polyethylene glycol (PEG) modified lipid micelles. Owing to paramagnetism, high near‐infrared (NIR) absorbance, and chelator‐free 99m Tc 4+ labeling of VS2, such VS2 @lipid‐PEG nanoparticles could be used for T1‐weighted magnetic resonance (MR), photoacoustic (PA), and single photon emission computed tomography (SPECT) tri‐modal imaging guided photothermal ablation of tumors. Importantly, along with the gradual degradation of VS2, our VS2 @lipid‐PEG nanoparticles exhibit effective body excretion without appreciable toxicity. The unique advantages of VS2 nanostructures with highly integrated functionalities and biodegradable behaviors mean they are promising for applications in cancer theranostics. Abstract : Ultra‐small VS2 nanodots converted from VS2 nanosheets are encapsulated inside PEG modified lipid micelles. The obtained VS2 @lipid‐PEG nanoparticles could be employed for tri‐modal imaging guided photothermal therapy. They exhibit effective degradation and body excretion without appreciable toxicity to the treated animals, and are thus promising for applications in cancer theranostics.