Angiopoietin‐like protein 8/betatrophin correlates with hepatocellular lipid content independent of insulin resistance in non‐alcoholic fatty liver disease patients. Issue 4 (15th January 2018)

• Record Type: Journal Article
• Authors: Hong, Beverly S; Liu, Juan; Zheng, Jing; Ke, Weijian; Huang, Zhimin; Wan, Xuesi; He, Xiaoying; Xiao, Haipeng; Li, Yanbing
• Is Part Of: Journal of diabetes investigation. Volume 9:Issue 4(2018)
• Page Start: 952
• Page End: 958
• Publication Date: 2018-01-15
• Subjects: Angiopoietin‐like protein 8 -- Hepatocellular lipid content -- Non‐alcoholic fatty liver disease; Diabetes -- Periodicals; Diabetes -- Research -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462005
• DOI: 10.1111/jdi.12792
• Languages: English
• ISSNs: 2040-1116

Abstract

Abstract: Aims/Introduction: To explore angiopoietin‐like protein 8 (ANGPTL‐8) levels, and its association with hepatocellular lipid content (HCL) and insulin resistance in patients with different extents of non‐alcoholic fatty liver disease (NAFLD). Materials and Methods: In 48 adults were recruited, of which 12 had no NAFLD (HCL < 5.5%; group 1), 18 had mild NAFLD (5.5% ≤ HCL < 10.0%; group 2) and 18 had moderate‐to‐severe NAFLD (HCL ≥ 10.0%; group 3). The peripheral insulin sensitivity of all participants was monitored by a hyperinsulinemic‐euglycemic clamp (M value), as well as the magnetic resonance image of HCL. Serum ANGPTL‐8, blood glucose levels and lipid profiles were also recorded in the study. Results: Group 3 had a worse metabolic profile, and had the highest ANGPTL‐8 level (1, 129 ± 351 pg/mL vs 742 ± 252 pg/mL, 765 ± 301 pg/mL, P = 0.001) compared with those in group 1 and group 2. In all metabolic profiles, HCL positively correlated the strongest with ANGPTL‐8 ( r = 0.436, P = 0.042). Multivariate stepwise linear regression analysis showed ANGPTL‐8 and alanine aminotransferase were independent determinants of HCL ( P = 0.002, P < 0.001, respectively), and these two indexes explained 67.4% of the variation of HCL ( P < 0.001). Conclusions: ANGPTL‐8 was positively correlated with hepatocellular lipid content independent of obesity and insulin resistance, indicating that ANGPTL‐8 might be a new and important important predictor of the severity of NAFLD. Abstract : ANGPTL‐8 was positively correlated with hepatocellular lipid content independent of obesity and insulin resistance, indicating that ANGPTL‐8 may be an important predictor of the severity of NAFLD.