A rhodamine‐triazole fluorescent chemodosimeter for Cu2+ detection and its application in bioimaging*. (17th July 2017)

• Record Type: Journal Article
• Authors: Wechakorn, Kanokorn; Prabpai, Samran; Suksen, Kanoknetr; Kanjanasirirat, Phongthon; Pewkliang, Yongyut; Borwornpinyo, Suparerk; Kongsaeree, Palangpon
• Is Part Of: Luminescence. Volume 33:Number 1(2018)
• Page Start: 64
• Page End: 70
• Publication Date: 2017-07-17
• Subjects: 1, 2, 3‐triazole -- bioimaging -- Cu2+‐selective chemodosimeter -- fluorescence detection -- rhodamine; Luminescence -- Periodicals; Bioluminescence -- Periodicals; Chemiluminescence -- Periodicals; Luminescence -- Periodicals; 535.35
• DOI: 10.1002/bio.3373
• Languages: English
• ISSNs: 1522-7235

Abstract

Abstract: A rhodamine‐based fluorescent chemodosimeter rhodamine hydrazide‐triazole (RHT) tethered with a triazole moiety was developed for Cu 2+ detection. In aqueous medium, the RHT probe exhibited high selectivity and sensitivity toward Cu 2+ among other metal ions. The addition of Cu 2+ triggered a fluorescence emission of RHT by 384‐fold (Φ = 0.33) based on a ring‐opening process and a subsequent hydrolysis reaction. Moreover, RHT also showed a selective colorimetric response toward Cu 2+ from colorless solution to pink, readily observed with the naked eye. The limit of detection of RHT for Cu 2+ was calculated to be 1 nM (0.06 ppb). RHT was successfully demonstrated to detect Cu 2+ in Chang liver cells by confocal fluorescence microscopy.