Multicontrast endomyocardial imaging by single‐channel high‐resolution cross‐polarization optical coherence tomography. Issue 4 (10th January 2018)

• Record Type: Journal Article
• Authors: Yao, Xinwen; Gan, Yu; Ling, Yuye; Marboe, Charles C.; Hendon, Christine P.
• Is Part Of: Journal of biophotonics. Volume 11:Issue 4(2018)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2018-01-10
• Subjects: imaging systems -- medical and biological imaging -- myocardium imaging -- optical coherence tomography -- polarization‐selective devices -- tissue characterization; Photonics -- Periodicals; Optical materials -- Periodicals; Optics -- Periodicals; Medical instruments and apparatus -- Periodicals; 621.3605
• DOI: 10.1002/jbio.201700204
• Languages: English
• ISSNs: 1864-063X

Abstract

Abstract : A single‐channel high‐resolution cross‐polarization (CP) optical coherence tomography (OCT) system is presented for multicontrast imaging of human myocardium in one‐shot measurement. The intensity and functional contrasts, including the ratio between the cross‐ and co‐polarization channels as well as the cumulative retardation, are reconstructed from the CP‐OCT readout. By comparing the CP‐OCT results with histological analysis, it is shown that the system can successfully delineate microstructures in the myocardium and differentiate the fibrotic myocardium from normal or ablated myocardium based on the functional contrasts provided by the CP‐OCT system. The feasibility of using A‐line profiles from the 2 orthogonal polarization channels to identify fibrotic myocardium, normal myocardium and ablated lesion is also discussed. Abstract : The ratio between the cross‐ and co‐polarization channel intensities is a typical cross‐polarization‐optical coherence tomography (CP‐OCT) contrast. Difference in CP‐OCT contrasts of ablated lesion, normal myocardium and fibrotic myocardium suggests the feasibility of using CP‐OCT for delineation of myocardial fibrosis in human myocardium.