Case of Primary Isolated Subconjunctival IgG4-Related Disease. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: Lee, Hyo Seok; Choi, Won; Kim, Ga Eon; Yoon, Kyung Chul
• Is Part Of: Cornea. Volume 37:Issue 7(2018)
• Publication Date: 2018-07
• Subjects: conjunctiva -- IgG4-related disease -- immunoglobulin -- subconjunctiva; Cornea -- Periodicals; Cornea -- Periodicals; Cornée -- Périodiques; 617.719
• DOI: 10.1097/ICO.0000000000001566
• Languages: English
• ISSNs: 0277-3740

Abstract

Abstract : Purpose: To report a case of isolated subconjunctival ocular adnexal IgG4-related disease that met the diagnostic criteria according to the Japanese Ministry of Health, Labour and Welfare's 2011 guidelines. Methods: We report a case of a 56-year-old woman with a left subconjunctival mass for 3 months. Excisional biopsy was performed. Postoperatively, the patient underwent systemic and radiologic evaluations for IgG4-related disease. Results: The clinicopathologic study revealed storiform fibrosis and lymphoplasmacytic infiltration, with increased IgG4-positive plasma cells and an IgG4/IgG-positive plasma cell ratio of 40%. Serum IgG4 and IgG levels were slightly elevated. Systemic involvement was not detected. Conclusions: IgG4-related disease is well known in the orbit and ocular adnexa, particularly the lacrimal gland. However, subconjunctival involvement should be recognized as a possible presentation for this entity.