OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY FEATURES OF CHOROIDAL NEOVASCULARIZATION ASSOCIATED WITH CHOROIDAL NEVUS. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: Pellegrini, Marco; Corvi, Federico; Say, Emil A. T.; Shields, Carol L.; Staurenghi, Giovanni
• Is Part Of: Retina. Volume 38:Issue 7(2018)
• Publication Date: 2018-07
• Subjects: eye -- choroidal nevus -- choroidal neovascularization -- fluorescein angiography -- optical coherence tomography -- optical coherence tomography angiography -- photodynamic therapy -- VEGF; Retina -- Diseases -- Periodicals; Retinal Diseases; Vitreous Body; 617.735
• DOI: 10.1097/IAE.0000000000001730
• Languages: English
• ISSNs: 0275-004X

Abstract

Abstract : Purpose: To describe the imaging features of choroidal neovascularization (CNV) associated with choroidal nevus using optical coherence tomography angiography (OCT-A) imaging. Methods: Retrospective observational case series. Patients with CNV secondary to choroidal nevus underwent full imaging examination including fundus photography, fluorescein angiography, indocyanine green angiography, spectral domain OCT, and OCT-A. The OCT-A features were analyzed and correlated with conventional angiography findings and spectral domain OCT. Results: There were 11 eyes from 11 patients (6 men and 5 women, mean age of 65 ± 20.4 years) included in the analysis. Fluorescein angiography and indocyanine green angiography disclosed CNV in 90% and 83%, respectively. Optical coherence tomography angiography displayed CNV network in 11 eyes (100%) and the pattern was classified as "sea-fan" in 8 (73%) and "long filamentous linear vessels" in 3 (27%) eyes. Distinct from CNV, intrinsic vasculature within the nevus was observed in six eyes (55%), corresponding to those with chronic retinal pigment epithelium changes. Conclusion: Optical coherence tomography angiography is a useful imaging technique to disclose CNV associated with choroidal nevus. Despite the presence of intraretinal or subretinal fluid and hemorrhage, OCT-A revealed the CNV in all cases, results noninferior to indocyanine green angiography. This imaging modality can be useful for analysis of long-standing nevi with related exudation. Abstract : Optical coherence tomography angiography of 11 eyes with choroidal nevus and overlying choroidal neovascularization disclosed neovascular network in all cases and additional intrinsic vasculature with the nevus in 6 eyes.