Extensive Necrotic Skin Lesions Due to Post-varicella Protein S Deficiency. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: De Geyer, Aymeric; Robert, Guillaume; Marleix, Sylvette; Fraisse, Bernard; Lucas, Grégory; Tattevin, Pierre; Violas, Philippe
• Is Part Of: Pediatric infectious disease journal. Volume 37:Issue 7(2018)
• Publication Date: 2018-07
• Subjects: varicella -- purpura -- protein S -- plasmapheresis; Communicable diseases in children -- Periodicals; Infection in children -- Periodicals; 618.929
• DOI: 10.1097/INF.0000000000001868
• Languages: English
• ISSNs: 0891-3668

Abstract

Abstract : Postvaricella protein S deficiency is a rare and severe disease. We report a case of extensive necrotic skin lesions of acute onset 7 days after varicella in a 4-year-old girl. Protein S antigen and activity were <10%, and antiprotein S antibodies were detected. She was treated with anticoagulation, plasmapheresis and fresh frozen plasma. She survived but required leg amputation. Abstract : Supplemental Digital Content is available in the text.