Increased mRNA Levels of TCF7L2 and MYC of the Wnt Pathway in Tg-ArcSwe Mice and Alzheimer's Disease Brain. (5th December 2010)

• Record Type: Journal Article
• Authors: Blom, Elin S.; Wang, Yijing; Skoglund, Lena; Hansson, Anita C.; Ubaldi, Massimo; Lourdusamy, Anbarasu; Sommer, Wolfgang H.; Mielke, Matthew; Hyman, Bradley T.; Heilig, Markus; Lannfelt, Lars; Nilsson, Lars N. G.; Ingelsson, Martin
• Other Names: Hiltunen Mikko Academic Editor.
• Is Part Of: International journal of alzheimer's disease. Volume 2011(2011)
• Publication Date: 2010-12-05
• Subjects: Alzheimer's disease -- Periodicals; 616.831005
• DOI: 10.4061/2011/936580
• Languages: English
• ISSNs: 2090-8024

Abstract

Abstract : Several components in the Wnt pathway, including β -catenin and glycogen synthase kinase 3 beta, have been implied in AD pathogenesis. Here, mRNA brain levels from five-month-old tg-ArcSwe and nontransgenic mice were compared using Affymetrix microarray analysis. With surprisingly small overall changes, Wnt signaling was the most affected pathway with altered expression of nine genes in tg-ArcSwe mice. When analyzing mRNA levels of these genes in human brain, transcription factor 7-like 2 ( TCF7L2 ) and v-myc myelocytomatosis viral oncogene homolog ( MYC ), were increased in Alzheimer's disease (AD) (P < .05 ). Furthermore, no clear differences in TCF7L2 and MYC mRNA were found in brains with frontotemporal lobar degeneration, suggesting that altered regulation of these Wnt-related genes could be specific to AD. Finally, mRNA levels of three neurogenesis markers were analyzed. Increased mRNA levels of dihydropyrimidinase-like 3 were observed in AD brain, suggesting that altered Wnt pathway regulation may signify synaptic rearrangement or neurogenesis.