Aβ Internalization by Neurons and Glia. (3rd January 2011)

• Record Type: Journal Article
• Authors: Mohamed, Amany; Posse de Chaves, Elena
• Other Names: Eckert Anne Academic Editor.
• Is Part Of: International journal of alzheimer's disease. Volume 2011(2011)
• Publication Date: 2011-01-03
• Subjects: Alzheimer's disease -- Periodicals; 616.831005
• DOI: 10.4061/2011/127984
• Languages: English
• ISSNs: 2090-8024

Abstract

Abstract : In the brain, the amyloid β peptide (A β ) exists extracellularly and inside neurons. The intracellular accumulation of A β in Alzheimer's disease brain has been questioned for a long time. However, there is now sufficient strong evidence indicating that accumulation of A β inside neurons plays an important role in the pathogenesis of Alzheimer's disease. Intraneuronal A β originates from intracellular cleavage of APP and from A β internalization from the extracellular milieu. We discuss here the different molecular mechanisms that are responsible for A β internalization in neurons and the links between A β internalization and neuronal dysfunction and death. A brief description of A β uptake by glia is also presented.