Safety and Outcome Measures of First-in-Human Intraperitoneal α Radioimmunotherapy With 212Pb-TCMC-Trastuzumab. (July 2018)

• Record Type: Journal Article
• Authors: Meredith, Ruby F.; Torgue, Julien J.; Rozgaja, Tania A.; Banaga, Eileen P.; Bunch, Patty W.; Alvarez, Ronald D.; Straughn, J. Michael; Dobelbower, Michael C.; Lowy, Andrew M.
• Is Part Of: American journal of clinical oncology. Volume 41:Number 7(2018)
• Publication Date: 2018-07
• Subjects: Pb-212-radioimmunotherapy -- cancer -- ovarian -- tumor marker -- intraperitoneal; Cancer -- Treatment -- Periodicals; Oncology -- Periodicals; Tumors -- Periodicals; 616.994005
• DOI: 10.1097/COC.0000000000000353
• Languages: English
• ISSNs: 0277-3732

Abstract

Abstract : Purpose: One-year monitoring of patients receiving intraperitoneal (IP) 212 Pb-TCMC-trastuzumab to provide long-term safety and outcome data. A secondary objective was to study 7 tumor markers for correlation with outcome. Methods: Eighteen patients with relapsed intra-abdominal human epidermal growth factor receptor-2 expressing peritoneal metastases were treated with a single IP infusion of 212 Pb-TCMC-trastuzumab, delivered <4 h after 4 mg/kg IV trastuzumab. Seven tumor markers were studied for correlation with outcome. Results: Six dose levels (7.4, 9.6, 12.6, 16.3, 21.1, 27.4 MBq/m 2 ) were well tolerated with early possibly agent-related adverse events being mild, transient, and not dose dependent. These included asymptomatic, abnormal laboratory values. No late renal, liver, cardiac, or other toxicity was noted up to 1 year. There were no clinical signs or symptoms of an immune response to 212 Pb-TCMC-trastuzumab, and assays to detect an immune response to this conjugate were negative for all tested. Tumor marker studies in ovarian cancer patients showed a trend of decreasing Cancer antigen 72-4 (CA 72-4) aka tumor-associated glycoprotein 72 (TAG-72) and tumor growth with increasing administered radioactivity. Other tumor markers, including carbohydrate antigen (CA125), human epididymis protein 4 (HE-4), serum amyloid A (SAA), mesothelin, interleukin-6 (IL-6), and carcinoembryonic antigen (CEA) did not correlate with imaging outcome. Conclusions: IP 212 Pb-TCMC-trastuzumab up to 27 MBq/m 2 seems safe for patients with peritoneal carcinomatosis who have failed standard therapies. Serum TAG-72 levels better correlated to imaging changes in ovarian cancer patients than the more common tumor marker, CA125.