A Review and Meta-Analysis of Occupational Titanium Dioxide Exposure and Lung Cancer Mortality. Issue 7 (July 2018)

• Record Type: Journal Article
• Authors: Le, Hien Q.; Tomenson, John A.; Warheit, David B.; Fryzek, Jon P.; Golden, Ashley P.; Ellis, Elizabeth D.
• Is Part Of: Journal of occupational and environmental medicine. Volume 60:Issue 7(2018)
• Publication Date: 2018-07
• Subjects: Cox regression -- lung cancer -- lung particle overload -- meta-analysis -- non-malignant respiratory disease -- occupational -- poorly soluble particulates -- titanium dioxide; Medicine, Industrial -- Periodicals; Environmental health -- Periodicals; Occupational Medicine -- Periodicals; Environmental Medicine -- Periodicals; Environmental health; Medicine, Industrial; Periodicals; Electronic journals; 616.9803
• DOI: 10.1097/JOM.0000000000001314
• Languages: English
• ISSNs: 1076-2752

Abstract

Abstract : Objective: A review of studies of occupational titanium dioxide (TiO2 ) exposure was conducted, and results from the three industry-based cohort mortality studies were summarized using meta-analysis. Methods: Summary standardized mortality ratios (SSMR) and summary Cox regression coefficients from exposure–response models were derived using random effects models. Results: Results from studies of 24, 312 TiO2 production workers were combined. SSMRs for lung cancer, all causes, all cancer, and non-malignant respiratory disease were 1.10 (95% confidence interval [CI]: 0.91 to 1.32), 0.85 (95% CI: 0.81 to 0.89), 0.92 (95% CI: 0.82 to 1.03), and 0.85 (95% CI: 0.71 to 1.02), respectively. For lung cancer, the summary hazard ratio for a 1 mg/m 3 year increase in cumulative exposure was 0.999 (0.997 to 1.002). Conclusions: Consistent with other published qualitative reviews, there is no clear evidence of an association between occupational exposure to TiO2 and lung cancer.