Management of herpes simplex virus epithelial keratitis. Issue 4 (July 2018)

• Record Type: Journal Article
• Authors: Roozbahani, Mehdi; Hammersmith, Kristin M.
• Is Part Of: Current opinion in ophthalmology. Volume 29:Issue 4(2018)
• Publication Date: 2018-07
• Subjects: antiviral -- epithelial keratitis -- herpes simplex virus -- resistance -- vaccine; Ophthalmology -- Periodicals; Eye Diseases -- Indexes; Eye Diseases -- Periodicals; Review Literature -- Indexes; Review Literature -- Periodicals; Vision Disorders -- Indexes; Vision Disorders -- Periodicals; 617.7
• DOI: 10.1097/ICU.0000000000000483
• Languages: English
• ISSNs: 1040-8738

Abstract

Abstract : Purpose of review: To review recent advancements in the management of herpes simplex virus (HSV) epithelial keratitis. Recent findings: Trifluridine eye drop, acyclovir (ACV) ointment, ganciclovir gel, and oral ACV are still the main therapeutic agents. Cryopreserved amniotic membrane has been recently used as an adjuvant treatment. Resistance to ACV has become a concerning issue. The animal models of HSV vaccine are able to reduce HSV keratitis. New antivirals are under development. Summary: Current cases of HSV epithelial keratitis are manageable with available medications, but new advancements are required to decrease disease burden in the future. HSV vaccine can be revolutionary.