Neurobiology of Memory and Anxiety: From Genes to Behavior. (9th January 2007)

• Record Type: Journal Article
• Authors: Kalueff, Allan V.
• Other Names: Chapouthier Georges Academic Editor.
• Is Part Of: Journal of neural transplantation & plasticity. Volume 2007(2007)
• Publication Date: 2007-01-09
• Subjects: Nerve tissue -- Transplantation -- Periodicals; Neuroplasticity -- Periodicals; Nerve tissue -- Transplantation; Neuroplasticity; Neuronal Plasticity -- Periodicals; Computer network resources; Periodicals; Electronic journals; 612.82
• DOI: 10.1155/2007/78171
• Languages: English
• ISSNs: 0792-8483

Abstract

Abstract : Interaction of anxiety and memory represents an essential feature of CNS functioning. This paper reviews experimental data coming from neurogenetics, neurochemistry, and behavioral pharmacology (as well as parallel clinical findings) reflecting different mechanisms of memory-anxiety interplay, including brain neurochemistry, circuitry, pharmacology, neuroplasticity, genes, and gene-environment interactions. It emphasizes the complexity and nonlinearity of such interplay, illustrated by a survey of anxiety and learning/memory phenotypes in various genetically modified mouse models that exhibit either synergistic or reciprocal effects of the mutation on anxiety levels and memory performance. The paper also assesses the putative role of different neurotransmitter systems and neuropeptides in the regulation of memory processes and anxiety, and discusses the role of neural plasticity in these mechanisms.