Spontaneous Plasticity of Multineuronal Activity Patterns in Activated Hippocampal Networks. (28th May 2008)

• Record Type: Journal Article
• Authors: Usami, Atsushi; Matsuki, Norio; Ikegaya, Yuji
• Other Names: Bramham Clive Academic Editor.
• Is Part Of: Journal of neural transplantation & plasticity. Volume 2008(2008)
• Publication Date: 2008-05-28
• Subjects: Nerve tissue -- Transplantation -- Periodicals; Neuroplasticity -- Periodicals; Nerve tissue -- Transplantation; Neuroplasticity; Neuronal Plasticity -- Periodicals; Computer network resources; Periodicals; Electronic journals; 612.82
• DOI: 10.1155/2008/108969
• Languages: English
• ISSNs: 0792-8483

Abstract

Abstract : Using functional multineuron imaging with single-cell resolution, we examined how hippocampal networks by themselves change the spatiotemporal patterns of spontaneous activity during the course of emitting spontaneous activity. When extracellular ionic concentrations were changed to those that mimicked in vivo conditions, spontaneous activity was increased in active cell number and activity frequency. When ionic compositions were restored to the control conditions, the activity level returned to baseline, but the weighted spatial dispersion of active cells, as assessed by entropy-based metrics, did not. Thus, the networks can modify themselves by altering the internal structure of their correlated activity, even though they as a whole maintained the same level of activity in space and time.