Increased depression symptom score in newly diagnosed type 2 diabetes patients. (March 2018)

• Record Type: Journal Article
• Authors: Rathmann, Wolfgang; Kuß, Oliver; Anderson, Dörte; Busch, Stefan; Hahn, Michael; Engelhard, Johanna; Zou, Ming; Kostev, Karel
• Is Part Of: Psychiatry research. Volume 261(2018)
• Page Start: 259
• Page End: 263
• Publication Date: 2018-03
• Subjects: Type 2 diabetes -- Depression -- Primary care -- Diabetes distress; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.12.091
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: The aim was to investigate the association between diabetes duration and depressive symptoms in type 2 diabetes. The DIAREG registry used data of a nationwide general medicine practice database (Disease Analyzer, Germany) augmented by prospective data from patient reported outcomes (PRO) including Center of Epidemiological Studies Depression Scale (CES-D: <16 vs. ≥16) and the SF-36. Multiple logistic regression models were used to investigate the association of diabetes duration with PROs. Overall, 1807 type 2 diabetes patients were registered in 108 practices. From 270 (15%) patients complete PRO could be collected, which were similar with respect to age, sex, body mass index, HbA1c, diabetes duration and treatment to patients with incomplete data (p≥0.05). Patients with a longer diabetes duration (reference: <2 years) displayed a significantly increased odds of having no indication of depression (CES-D <16: 66%) (Odds Ratio, 95%CI: 2-<5 years: 5.9, 1.2–29.6; 5-<10 years: 6.2, 1.3–28.7; ≥10 years: 5.6, 1.2–23.1), after adjusting for age, sex, BMI, diabetes complications, antidepressants and glucose-lowering treatment. Patients with <2 years diabetes duration also exhibited a significantly decreased mean mental component score (SF-36: <2 years: 50, 2-<5 years: 69). In type 2 diabetes with a short duration an increased depressive symptom score was observed. Highlights: Data on depression and quality of life in newly diagnosed type 2 diabetes are scarce. Patients with newly diagnosed type 2 diabetes have an elevated depression score and a reduced mental quality of life. Most likely the increased depression score is related to distress due to diabetes. Depression and low quality of life impair the motivation for diabetes self-management.