No differences in manic-like behaviors between voluntary ethanol and water drinking in Lateral Hypothalamic Kindled (LHK) alcohol preferring rats. (March 2018)

• Record Type: Journal Article
• Authors: Gawad, Noha Abdel; Mohamed, Khalid; Choi, Doo-Sup; Abulseoud, Osama A.
• Is Part Of: Psychiatry research. Volume 261(2018)
• Page Start: 186
• Page End: 189
• Publication Date: 2018-03
• Subjects: Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.12.075
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: This study investigates phenotypic differences of manic-like behaviors during voluntary ethanol (vs. water) intake in alcohol preferring (P) rats, using the lateral hypothalamus kindled (LHK) rat mania model. Alcohol preferring (P) rats exhibited classic manic-like behaviors during kindling and the post-kindling intervals in all coded behaviors ( p < 0.0001), lending further validity to the lateral hypothalamus kindled rat as a useful model to study mania. However, there was no significant phenotypic difference between alcohol and water drinking alcohol preferring (P) rats. Highlights: LHK rat model remains a valid model for mania. No phenotypic differences in LHK model with alcohol. Further study needed for comorbid mania and alcoholism.