Thiol/disulphide homeostasis in bipolar disorder. (March 2018)

• Record Type: Journal Article
• Authors: Erzin, Gamze; Kotan, Vahap Ozan; Topçuoğlu, Canan; Özkaya, Güven; Erel, Özcan; Yüksel, Rabia Nazik; Ürer, Emre; Aydemir, Makbule Çiğdem; Göka, Erol
• Is Part Of: Psychiatry research. Volume 261(2018)
• Page Start: 237
• Page End: 242
• Publication Date: 2018-03
• Subjects: Oxidative stress -- Mania -- Remission -- Mood disorder -- Oxidative markers; Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2017.12.062
• Languages: English
• ISSNs: 0165-1781

Abstract

Abstract: Bipolar disorder (BD) patients have increased oxidative stress, which can disturb thiol/disulphide homeostasis, causing disulphide formation. The aim of the study is to investigate dynamic thiol/disulphide (SH/SS) homeostasis in BD patients, which is a novel evaluation method of oxidative status. Ninety-four BD patients (50 in the manic episode and 44 in remission) and 44 healthy controls were included in the study. Blood serum native thiol (SH) and total thiol (ToSH) concentrations were measured in a paired test. The half value of the difference between native thiol and total thiol concentrations was calculated as the disulphide (SS) bond amount. Serum native thiol levels of the mania group were found to be lower than the remission and the control groups. There was a significant difference between the remission group and the control group in terms of native thiol. Serum total thiol level was lower in mania group than the control group. Detection of oxidative molecules for BD could be helpful, especially in treatment, follow-up periods and reducing morbidity. The results of our study besides the data available in the literature support that thiol and disulphide levels are useful markers for BD and promising therapeutic targets in terms of future pharmacological modulation. Highlights: We evaluated thiol/disulphide homeostasis in patients with bipolar disorder. Native thiol and total thiol concentrations were found lower in patients with mania than the control group. Disulphide/native thiol ratio was higher in mania group than the control group.