Comparison of children diagnosed with cerebral palsy in a private cord blood bank to an epidemiological sample. (September 2018)

• Record Type: Journal Article
• Authors: Mazonson, Peter; Kane, Mark; Colberg, Kelin; Harris, Heather; Brown, Heather; Mohr, Andrew; Santas, Chris; Sandler, Adrian
• Is Part Of: Research in developmental disabilities. Volume 80(2018)
• Page Start: 153
• Page End: 160
• Publication Date: 2018-09
• Subjects: Cerebral palsy -- Regenerative medicine -- Hematopoietic stem cells -- Umbilical cord blood -- Web-based research -- Private cord blood bank; Developmental disabilities -- Periodicals; Developmentally disabled -- Research -- United States -- Periodicals; Developmentally disabled children -- Education -- Research -- United States -- Periodicals; Developmental Disabilities -- Periodicals; Disabled -- Periodicals; Mental Retardation -- rehabilitation -- Periodicals; Personnes atteintes de troubles du développement -- Recherche -- États-Unis -- Périodiques; Enfants atteints de troubles du développement -- Éducation -- Recherche -- États-Unis -- Périodiques; Développement, Troubles du -- Recherche -- États-Unis -- Périodiques; 616.858800
• DOI: 10.1016/j.ridd.2018.06.011
• Languages: English
• ISSNs: 0891-4222

Abstract

Highlights: LUSTRE studies children with CP from a large private US cord blood bank. LUSTRE subjects with CP were compared to a US population-based CP cohort. The two groups differed demographically but mobility, functional status, and comorbidities were similar. LUSTRE may be a valuable data source for the characterization of individuals with CP, including those seeking CB infusions. Abstract: Background: Although cord blood (CB) stem cell research is being conducted for treatment of cerebral palsy (CP), little is known about children with CP and stored CB. Aims: To compare demographic and clinical characteristics of children with CP and stored CB to children with CP identified in a population-based study. Methods and Procedures: The Longitudinal Umbilical Stem cell monitoring and Treatment REsearch (LUSTRE®) Registry recruited children from the largest US private CB bank. Demographics, co-morbidities, and gross motor function (GMFCS level and walking ability) were collected and, where possible, compared with the CDC's Autism and Developmental Disabilities Monitoring (ADDM) Network. Outcomes and Results: 114 LUSTRE participants were compared to 451 ADDM participants. LUSTRE participants were more likely to be white, but sex distribution was similar. Co-morbidities (autism and epilepsy) and functional mobility were also similar. Conclusions and Implications: The results of this analysis suggest that while children diagnosed with CP and with access to stored CB differ from a broader population sample in terms of demographics, they have similar clinical severity and comorbidity profiles. As such, LUSTRE may serve as a valuable source of data for the characterization of individuals with CP, including individuals who have or will receive CB infusions.