Synthesis, Anti-Inflammatory Activity, and In Silico Study of Novel Diclofenac and Isatin Conjugates. (12th June 2018)

• Record Type: Journal Article
• Authors: Ibrahim, Musab Mohamed; Elsaman, Tilal; Al-Nour, Mosab Yahya
• Other Names: You Qi-Dong Academic Editor.
• Is Part Of: International journal of medicinal chemistry. Volume 2018(2018)
• Publication Date: 2018-06-12
• Subjects: Pharmaceutical chemistry -- Periodicals; Chemistry, Pharmaceutical; Pharmaceutical chemistry; Periodicals; 615.19
• DOI: 10.1155/2018/9139786
• Languages: English
• ISSNs: 2090-2069

Abstract

Abstract : The design, synthesis, and development of novel non-steroidal anti-inflammatory drugs (NSAIDs) with better activity and lower side effects are respectable area of research. Novel Diclofenac Schiff's bases (M1, M2, M4, M7, andM8 ) were designed and synthesized, and their respective chemical structures were deduced using various spectral tools (IR, 1 H NMR, 13 C NMR, and MS). The compounds were synthesized via Schiff's condensation reaction and their anti-inflammatory activity was investigated applying the Carrageenan-induced paw edema model against Diclofenac as positive control. Percentage inhibition of edema indicated that all compounds were exhibiting a comparable anti-inflammatory activity as Diclofenac. Moreover, the anti-inflammatory activity was supported via virtual screening using molecular docking study. Interestingly compoundM2 showed the highest in vivo activity (61.32% inhibition) when compared to standard Diclofenac (51.36% inhibition) as well as the best binding energy score (-10.765) and the virtual screening docking score (-12.142).