Microwave-Assisted Synthesis and Biological Evaluation of Dihydropyrimidinone Derivatives as Anti-Inflammatory, Antibacterial, and Antifungal Agents. (15th April 2013)

• Record Type: Journal Article
• Authors: Bhatewara, Anjna; Jetti, Srinivasa Rao; Kadre, Tanuja; Paliwal, Pradeep; Jain, Shubha
• Other Names: You Qidong Academic Editor.
• Is Part Of: International journal of medicinal chemistry. Volume 2013(2013)
• Publication Date: 2013-04-15
• Subjects: Pharmaceutical chemistry -- Periodicals; Chemistry, Pharmaceutical; Pharmaceutical chemistry; Periodicals; 615.19
• DOI: 10.1155/2013/197612
• Languages: English
• ISSNs: 2090-2069

Abstract

Abstract : A simple protocol for the efficient preparation of aryl and heteroaryl substituted dihydropyrimidinone has been achieved via initial Knoevenagel, subsequent addition, and final cyclization of aldehyde, ethylcyanoacetate, and guanidine nitrate in the presence of piperidine as a catalyst in solvent-free under microwave irradiation. The synthesized compounds showed a good anti-inflammatory, antibacterial, and antifungal activity.