Pharmacophore Modelling and Synthesis of Quinoline-3-Carbohydrazide as Antioxidants. (14th February 2011)

• Record Type: Journal Article
• Authors: El Bakkali, Mustapha; Ismaili, Lhassane; Tomassoli, Isabelle; Nicod, Laurence; Pudlo, Marc; Refouvelet, Bernard
• Other Names: Rossello Armando Academic Editor.
• Is Part Of: International journal of medicinal chemistry. Volume 2011(2011)
• Publication Date: 2011-02-14
• Subjects: Pharmaceutical chemistry -- Periodicals; Chemistry, Pharmaceutical; Pharmaceutical chemistry; Periodicals; 615.19
• DOI: 10.1155/2011/592879
• Languages: English
• ISSNs: 2090-2069

Abstract

Abstract : From well-known antioxidants agents, we developed a first pharmacophore model containing four common chemical features: one aromatic ring and three hydrogen bond acceptors. This model served as a template in virtual screening of Maybridge and NCI databases that resulted in selection of sixteen compounds. The selected compounds showed a good antioxidant activity measured by three chemical tests: DPPH radical, OH ∘ radical, and superoxide radical scavenging. New synthetic compounds with a good correlation with the model were prepared, and some of them presented a good antioxidant activity.