Synthesis and Evaluation of Baylis-Hillman Reaction Derived Imidazole and Triazole Cinnamates as Antifungal Agents. (16th October 2018)

• Record Type: Journal Article
• Authors: Nelson, Grady L.; Williams, Michael J.; Jonnalagadda, Shirisha; Alam, Mohammad A.; Mereddy, Gautam; Johnson, Joseph L.; Jonnalagadda, Sravan K.
• Other Names: Natalini Benedetto Academic Editor.
• Is Part Of: International journal of medicinal chemistry. Volume 2018(2018)
• Publication Date: 2018-10-16
• Subjects: Pharmaceutical chemistry -- Periodicals; Chemistry, Pharmaceutical; Pharmaceutical chemistry; Periodicals; 615.19
• DOI: 10.1155/2018/5758076
• Languages: English
• ISSNs: 2090-2069

Abstract

Abstract : Allylic acetates derived from Baylis-Hillman reaction undergo efficient nucleophilic isomerization with imidazoles and triazoles to provide imidazolylmethyl and triazolylmethyl cinnamates stereoselectively. Antifungal evaluation of these derivatives against Cryptococcus neoformans exhibits good minimum inhibitory concentration values. These compounds exhibit low toxicity in proliferating MCF-7 breast cancer cell line. Structure activity relationship studies indicate that halogenated aromatic derivatives provide better antifungal activity.