Synthesis and Biological Activity of Arylspiroborate Salts Derived from Caffeic Acid Phenethyl Ester. (5th March 2015)

• Record Type: Journal Article
• Authors: Hébert, Martin J. G.; Flewelling, Andrew J.; Clark, Trevor N.; Levesque, Natalie A.; Jean-François, Jacques; Surette, Marc E.; Gray, Christopher A.; Vogels, Christopher M.; Touaibia, Mohamed; Westcott, Stephen A.
• Other Names: Bednarski Patrick Academic Editor.
• Is Part Of: International journal of medicinal chemistry. Volume 2015(2015)
• Publication Date: 2015-03-05
• Subjects: Pharmaceutical chemistry -- Periodicals; Chemistry, Pharmaceutical; Pharmaceutical chemistry; Periodicals; 615.19
• DOI: 10.1155/2015/418362
• Languages: English
• ISSNs: 2090-2069

Abstract

Abstract : Two novel boron compounds containing caffeic acid phenethyl ester (CAPE) derivatives have been prepared and characterized fully. These new compounds and CAPE have been investigated for potential antioxidant and antimicrobial properties and their ability to inhibit 5-lipoxygenase and whether chelation to boron improves their biological activity. Sodium salt4 was generally more active than ammonium salt5 in the biological assays and surpassed the radical scavenging ability of CAPE. Compounds4 and5 were more active than CAPE and Zileuton in human polymorphonuclear leukocytes. These results clearly show the effectiveness of the synthesized salts as transporter of CAPE.