Age-Related White Matter Changes. (23rd August 2011)

• Record Type: Journal Article
• Authors: Xiong, Yun Yun; Mok, Vincent
• Other Names: Pantoni Leonardo Academic Editor.
• Is Part Of: Journal of aging research. Volume 2011(2011)
• Publication Date: 2011-08-23
• Subjects: Aging -- Periodicals; Aging -- Research -- Periodicals; 612.6705
• DOI: 10.4061/2011/617927
• Languages: English
• ISSNs: 2090-2204

Abstract

Abstract : Age-related white matter changes (WMC) are considered manifestation of arteriolosclerotic small vessel disease and are related to age and vascular risk factors. Most recent studies have shown that WMC are associated with a host of poor outcomes, including cognitive impairment, dementia, urinary incontinence, gait disturbances, depression, and increased risk of stroke and death. Although the clinical relevance of WMC has been extensively studied, to date, only very few clinical trials have evaluated potential symptomatic or preventive treatments for WMC. In this paper, we reviewed the current understanding in the pathophysiology, epidemiology, clinical importance, chemical biomarkers, and treatments of age-related WMC.