Cover Feature: Unveiling the Binding Modes of the Crystallophore, a Terbium‐based Nucleating and Phasing Molecular Agent for Protein Crystallography (Chem. Eur. J. 39/2018). Issue 39 (25th June 2018)

• Record Type: Journal Article
• Authors: Engilberge, Sylvain; Riobé, François; Wagner, Tristan; Di Pietro, Sebastiano; Breyton, Cécile; Franzetti, Bruno; Shima, Seigo; Girard, Eric; Dumont, Elise; Maury, Olivier
• Is Part Of: Chemistry. Volume 24:Issue 39(2018)
• Page Start: 9701
• Page End: 9701
• Publication Date: 2018-06-25
• Subjects: crystallophore -- lanthanides -- nucleating agent -- protein structure determination -- supramolecular chemistry; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201802734
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : The first clues on the origins of the peculiar abilities of crystallophore (Tb‐Xo4) are reported. Tb‐Xo4 is a terbium complex that allows both the nucleation of protein crystals and the solving of their structures. Herein, a detailed study of the binding of Tb‐Xo4 in a set of six structures is presented. It evidences the adaptability of the complex towards different crystallization conditions and protein environments, thanks to a variety of supramolecular interactions. The cover shows Tb‐Xo4/FprA protein co‐crystals and the related crystal packing that has been determined. The magnifying glass depicts a detailed view of a Tb‐Xo4 dimer binding site. More information can be found in the Communication by O. Maury, F. Riobé, E. Girard, E. Dumont, et al. onpage 9739 .