Cover Feature: Self‐assembly of Fluorescent Dehydroberberine Enhances Mitochondria‐Dependent Antitumor Efficacy (Chem. Eur. J. 39/2018). Issue 39 (25th June 2018)

• Record Type: Journal Article
• Authors: An, Ruibing; Gu, Zhanni; Sun, Haifeng; Hu, Yuxuan; Yan, Runqi; Ye, Deju; Liu, Hong
• Is Part Of: Chemistry. Volume 24:Issue 39(2018)
• Page Start: 9700
• Page End: 9700
• Publication Date: 2018-06-25
• Subjects: antitumor -- cell imaging -- dehydroberberine -- mitochondria -- self-assembly; Chemistry -- Periodicals; 540
• DOI: 10.1002/chem.201802840
• Languages: English
• ISSNs: 0947-6539

Abstract

Abstract : A fluorescent mitochondria‐targeting dehydroberberine (DH‐BBR) that could form organic nanoparticles by a lipophilic anion tetraphenylborate (TPB)‐mediated self‐assembly process was developed. The self‐assembled nanoparticles could remarkably enhance the uptake of DH‐BBR into tumor cells, induce significant mitochondrial dysfunction, and ultimately inhibit tumor growth in living mice. This study demonstrated the great potential of using self‐assembly approach to engineer mitochondria‐targeting small molecules for improved cancer therapy. More information can be found in the Full Paper by D. Ye, H. Liu, et al. onpage 9812 .