Alternative Cell Death Pathways and Cell Metabolism. (21st January 2013)

• Record Type: Journal Article
• Authors: Fulda, Simone
• Other Names: Cerella Claudia Academic Editor.
• Is Part Of: International journal of cell biology. Volume 2013(2013)
• Publication Date: 2013-01-21
• Subjects: Cytology -- Periodicals; Cell Biology; Cytology; Periodicals; Electronic journals -- Sciences; Electronic journals -- Biology; Periodicals; 571.6
• DOI: 10.1155/2013/463637
• Languages: English
• ISSNs: 1687-8876

Abstract

Abstract : While necroptosis has for long been viewed as an accidental mode of cell death triggered by physical or chemical damage, it has become clear over the last years that necroptosis can also represent a programmed form of cell death in mammalian cells. Key discoveries in the field of cell death research, including the identification of critical components of the necroptotic machinery, led to a revised concept of cell death signaling programs. Several regulatory check and balances are in place in order to ensure that necroptosis is tightly controlled according to environmental cues and cellular needs. This network of regulatory mechanisms includes metabolic pathways, especially those linked to mitochondrial signaling events. A better understanding of these signal transduction mechanisms will likely contribute to open new avenues to exploit our knowledge on the regulation of necroptosis signaling for therapeutic application in the treatment of human diseases.